About 500 new cases of neuroblastoma are diagnosed annually in Brazil. The Institute of Treatment of Childhood Cancer, Institute of the Child, Clinics Hospital, School of Medicine, and University of Sao Paolo (ITACI) in Sao Paolo, Brazil is one of the largest hospitals in the country providing cancer treatment for children from all socioeconomic backgrounds. CUMC is collaborating with ITACI to investigate the impact of nutrition status, body composition, and dietary intake, and their association with treatment outcomes and quality of life in children undergoing treatment for neuroblastoma.
CUMC is collaborating with Unidad De Oncologica Pediatrica (UNOP) in Guatemala City, the only academic pediatric cancer center in Guatemala, providing care to more than 400 cases annually, to examine the role of nutritional status on treatment-outcomes in children with acute lymphoblastic leukemia (ALL). The objective is to determine the association of nutritional status, physical activity, body composition with clinical outcomes in children undergoing treatment for ALL.
Dr. Ladas and colleagues are collaborating with the Hematology Oncology Unit, Advanced Pediatrics Center at the Post Graduate Institute of Medical Education and Research (PGIMER) in Chandigarh, to establish uniform levels of care through the validation of nutritional algorithm. The children participating in this study will be recruited from PGIMER and the research will be facilitated by the local investigators in Chandigarh.
In collaboration with Tata Memorial Hospital in Mumbai, IIPAN and its collaborators are evaluating the effect of malnutrition on the development of sarcopenic obesity in Indian children with acute lymphoblastic leukemia (ALL). The study will examine lifestyle factors, genetics, and demographic variables among Indian children and adolescents with ALL. The participants for the study will be children and adolescents undergoing treatment at Tata Memorial Hospital, the largest pediatric cancer center in South Asia.
A milti-country partnership has been established with Children’s Hospital Manuel de Jesus Rivera (CHMJR), a team of investigators in Monza, Italy and Columbia University. The collaborative group has established the infrastructure for the training of institutional personnel and research and for the provision of nutritional supplements and interventions. This collaborative effort will investigate the impact of a newly established nutritional program on the incidence and severity of malnutrition and treatment-related toxicities in children with solid tumors.
The Department of Pediatrics at the University of Pretoria and Stellenbosch University, have joined with Dr. Ladas to establish an African Nutritional Registry in Pediatric Oncology Units across South Africa. As part of the national cancer registry in South Africa, this novel study will systematically document the prevalence of malnutrition and the burden of nutritional conditions among children with cancer in South Africa. These efforts will establish clinical guidelines and educational/ research priorities.